Open AccessOncogenic potential of IDH1R132C mutant in cholangiocarcinoma development in mice
Author(s) -
Ning Ding,
Li Che,
Xiaolei Li,
Yan Liu,
Lijie Jiang,
Bin Fan,
Junyan Tao,
Xin Chen,
Jiafu Ji
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i6.2071
Subject(s) - h&e stain , pathology , sirius red , notch signaling pathway , immunohistochemistry , liver tumor , histology , hes1 , intrahepatic cholangiocarcinoma , carcinogenesis , staining , biology , medicine , cancer research , hepatocellular carcinoma , cancer , signal transduction , microbiology and biotechnology
To investigate whether IDH1R132C mutant in combination with loss of p53 and activated Notch signaling promotes intrahepatic cholangiocarcinoma (ICC) development.