Open AccessAuxiliary partial liver transplantation for acute liver failure using "high risk" grafts: Case report
Author(s) -
Weidong Duan,
Xitao Wang,
Hongguang Wang,
Wenbin Ji,
Hao Li,
Jiahong Dong
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i5.1919
Subject(s) - medicine , liver transplantation , hepatic encephalopathy , immunosuppression , encephalopathy , coma (optics) , fulminant hepatic failure , transplantation , surgery , steatosis , gastroenterology , cirrhosis , physics , optics
Acute liver failure (ALF) is a reversible disorder that is associated with an abrupt loss of hepatic mass, rapidly progressive encephalopathy and devastating complications. Despite its high mortality, an emergency liver transplantation nowadays forms an integral part in ALF management and has substantially improved the outcomes of ALF. Here, we report the case of a 32-year-old female patient who was admitted with grade IV hepatic encephalopathy (coma) following drug-induced ALF. We performed an emergency auxiliary partial orthotopic liver transplantation with a "high risk" graft (liver macrovesicular steatosis approximately 40%) from a living donor. The patient was discharged on postoperative day 57 with normal liver function. Weaning from immunosuppression was achieved 9 mo after transplantation. A follow-up using CT scan showed a remarkable increase in native liver volume and gradual loss of the graft. More than 6 years after the transplantation, the female now has a 4-year-old child and has returned to work full-time without any neurological sequelae.