Open AccessPost reperfusion syndrome during liver transplantation: From pathophysiology to therapy and preventive strategies
Author(s) -
Antonio Siniscalchi,
Lorenzo Gamberini,
Cristiana Laici,
Tommaso Bardi,
Giorgio Ercolani,
Luca Lorenzini,
Stefano Faenza
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i4.1551
Subject(s) - medicine , liver transplantation , intensive care medicine , pathophysiology , cochrane library , transplantation , medline , bioinformatics , confounding , randomized controlled trial , pathology , surgery , biology , political science , law
This review aims at evaluating the existing evidence regarding post reperfusion syndrome, providing a description of the pathophysiologic mechanisms involved and possible management and preventive strategies. A PubMed search was conducted using the MeSH database, "Reperfusion" AND "liver transplantation" were the combined MeSH headings; EMBASE and the Cochrane library were also searched using the same terms. 52 relevant studies and one ongoing trial were found. The concept of post reperfusion syndrome has evolved through years to a multisystemic disorder. The implications of the main organ, recipient and procedure related factors in the genesis of this complex syndrome are discussed in the text as the novel pharmacologic and technical approaches to reduce its incidence. However the available evidence about risk factors, physiopathology and preventive measures is still confusing, the presence of two main definitions and the numerosity of possible confounding factors greatly complicates the interpretation of the studies.