Open AccessHost restriction factors for hepatitis C virus
Author(s) -
Liya Zhou,
Leiliang Zhang
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i4.1477
Subject(s) - pathogenesis , hepatitis c virus , virology , biology , viral pathogenesis , host (biology) , host factors , viral replication , virus , hepacivirus , immunology , hepatitis c , genetics
Host-hepatitis C virus (HCV) interactions have both informed fundamental concepts of viral replication and pathogenesis and provided novel insights into host cell biology. These findings are illustrated by the recent discovery of host-encoded factors that restrict HCV infection. In this review, we briefly discuss these restriction factors in different steps of HCV infection. In each case, we discuss how these restriction factors were identified, the mechanisms by which they inhibit HCV infection and their potential contribution to viral pathogenesis.