Open AccessGenomic and epigenomic heterogeneity in molecular subtypes of gastric cancer
Author(s) -
Byungho Lim,
Jong Hwan Kim,
Mirang Kim,
SeonYoung Kim
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i3.1190
Subject(s) - epigenomics , microsatellite instability , dna methylation , cancer , subtyping , biology , genome instability , computational biology , disease , genomics , genetics , bioinformatics , genome , gene , medicine , dna , microsatellite , gene expression , dna damage , allele , computer science , programming language
Gastric cancer is a complex disease that is affected by multiple genetic and environmental factors. For the precise diagnosis and effective treatment of gastric cancer, the heterogeneity of the disease must be simplified; one way to achieve this is by dividing the disease into subgroups. Toward this effort, recent advances in high-throughput sequencing technology have revealed four molecular subtypes of gastric cancer, which are classified as Epstein-Barr virus-positive, microsatellite instability, genomically stable, and chromosomal instability subtypes. We anticipate that this molecular subtyping will help to extend our knowledge for basic research purposes and will be valuable for clinical use. Here, we review the genomic and epigenomic heterogeneity of the four molecular subtypes of gastric cancer. We also describe a mutational meta-analysis and a reanalysis of DNA methylation that were performed using previously reported gastric cancer datasets.