Open AccessAdvanced gastric cancer: What we know and what we still have to learn
Author(s) -
Federico Coccolini,
Giulia Montori,
Marco Ceresoli,
S. Cima,
M. Valli,
Gabriela Elisa Nita,
Arianna Heyer,
Federico Coccolini,
Luca Ansaloni
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i3.1139
Subject(s) - medicine , cancer , intraperitoneal chemotherapy , disease , chemotherapy , radiation therapy , cause of death , intensive care medicine , oncology , ovarian cancer
Gastric cancer is a common neoplastic disease and, more precisely, is the third leading cause of cancer death in the world, with differences amongst geographic areas. The definition of advanced gastric cancer is still debated. Different stadiating systems lead to slightly different stadiation of the disease, thus leading to variations between the single countries in the treatment and outcomes. In the present review all the possibilities of treatment for advanced gastric cancer have been analyzed. Surgery, the cornerstone of treatment for advanced gastric cancer, is analyzed first, followed by an investigation of the different forms and drugs of chemotherapy and radiotherapy. New frontiers in treatment suggest the growing consideration for intraperitoneal administration of chemotherapeutics and combination of traditional drugs with new ones. Moreover, the necessity to prevent the relapse of the disease leads to the consideration of administering intraperitoneal chemotherapy earlier in the therapeutical algorithm.