Open AccessRe-evaluation of classical prognostic factors in resectable ductal adenocarcinoma of the pancreas
Author(s) -
Daniel Åkerberg,
Daniel Ansari,
Roland Andersson
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i28.6424
Subject(s) - medicine , perineural invasion , resection margin , adenocarcinoma , pancreatic cancer , pancreatic ductal adenocarcinoma , pancreas , lymph node , oncology , pancreatectomy , incidence (geometry) , surgery , resection , cancer , radiology , physics , optics
Pancreatic ductal adenocarcinoma carries a poor prognosis with annual deaths almost matching the reported incidence rates. Surgical resection offers the only potential cure. Yet, even among patients that undergo tumor resection, recurrence rates are high and long-term survival is scarce. Various tumor-related factors have been identified as predictors of survival after potentially curative resection. These factors include tumor size, lymph node disease, tumor grade, vascular invasion, perineural invasion and surgical resection margin. This article will re-evaluate the importance of these factors based on recent publications on the topic, with potential implications for treatment and outcome in patients with pancreatic cancer.