Open AccessMicroRNA-21 promotes phosphatase gene and protein kinase B/phosphatidylinositol 3-kinase expression in colorectal cancer
Author(s) -
Weizhong Sheng,
YuSheng Chen,
Caixia Tu,
Juan He,
Bo Zhang,
Weidong Gao
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i24.5532
Subject(s) - pten , protein kinase b , pi3k/akt/mtor pathway , microrna , tensin , cancer research , biology , phosphatidylinositol , phosphatase , microbiology and biotechnology , kinase , gene expression , signal transduction , gene , phosphorylation , genetics
To explore the regulatory mechanism of the target gene of microRNA-21 (miR-21), phosphatase gene (PTEN), and its downstream proteins, protein kinase B (AKT) and phosphatidylinositol 3-kinase (PI3K), in colorectal cancer (CRC) cells.