Open Accessvon Willebrand factor antigen as a therapeutic target of portal hypertension in cirrhosis
Author(s) -
Georgios Kalambokis,
Gerasimos Baltayiannis,
Dimitrios Christodoulou
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i19.4786
Subject(s) - portal hypertension , von willebrand factor , cirrhosis , medicine , portal venous pressure , platelet , antigen , immunology , antithrombotic , gastroenterology
Increased thrombotic potential within the liver sinusoids due to local endothelial production of von Willebrand factor antigen macromolecules could represent an additional therapeutic target of portal hypertension in patients with cirrhosis. In this case, anti-inflammatory and antithrombotic drugs could modulate portal pressure by preventing the formation of intrahepatic platelet-induced microthrombi.