Open AccessMultidisciplinary management of nonfunctional neuroendocrine tumor of the pancreas
Author(s) -
Ian W. Folkert,
Paul T. Hernandez,
Robert E. Roses
Publication year - 2016
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v22.i11.3105
Subject(s) - neuroendocrine tumors , medicine , multidisciplinary approach , disease , pancreas , modalities , carcinoid heart disease , oncology , intensive care medicine , carcinoid syndrome , general surgery , social science , sociology
Pancreatic neuroendocrine tumors (PNETs) are a rare and diverse group of tumors; nonfunctional (NF) PNETs account for the majority of cases. Most patients with NF-PNETs have metastatic disease at the time of presentation. A variety of treatment modalities exist, including medical, liver directed, and surgical treatments. Aggressive surgical management is associated with prolonged survival, however available data are limited by selection bias and the frequent combination of PNETs with carcinoid tumors. Although few patients with metastatic disease will be cured, application of currently available therapies in a multidisciplinary setting can lead to excellent outcomes with prolonged patient survival.