Open AccessN-acetylcysteine treats intravenous amiodarone induced liver injury
Author(s) -
Matthew L. Mudalel,
Kartikeya P Dave,
James P. Hummel,
Steven F. Solga
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i9.2816
Subject(s) - amiodarone , medicine , acetylcysteine , liver injury , intensive care unit , pharmacology , pathogenesis , drug , anesthesia , gastroenterology , biology , atrial fibrillation , biochemistry , antioxidant
We report a case of intravenous (IV) amiodarone drug induced liver injury (DILI). The patient received IV N-acetylcysteine (NAC) which resulted in a rapid improvement in liver enzymes. While the specific mechanisms for the pathogenesis of IV amiodarone DILI and the therapeutic action of IV NAC are both unknown, this case strongly implies at least some commonality. Because IV amiodarone is indicated for the treatment of serious cardiac arrhythmias in an intensive care unit setting, some degree of ischemic hepatitis is likely a cofactor in most cases.