Open AccessEsophageal stenosis with sloughing esophagitis: A curious manifestation of graft-vs-host disease
Author(s) -
Daniel Trabulo,
Sara Ferreira,
Pedro Lage,
Rafaela L. Rego,
Gustavo Machado Teixeira,
António Dias Pereira
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i30.9217
Subject(s) - medicine , dysphagia , sloughing , balloon dilation , esophageal stricture , stenosis , esophagitis , surgery , context (archaeology) , endoscopy , gastroenterology , esophagus , graft versus host disease , swallowing , disease , transplantation , pathology , balloon , reflux , paleontology , biology
We report a case of a 56-year-old woman with a history of allogenic bone marrow transplantation for two years, complaining with dysphagia and weight loss. Upper endoscopy revealed esophageal stenosis and extensive mucosa sloughing. Biopsies confirmed the diagnosis of graft-vs-host disease (GVHD). Balloon dilation, corticosteroids and cyclosporin resulted in marked clinical improvement. Gastrointestinal tract is involved in the majority of patients with chronic GVHD. Esophageal manifestations are rare and include vesiculobullous disease, ulceration, esophageal webs, casts or strictures. Sloughing esophagitis along with severe stenosis requiring endoscopic dilation has never been reported in this context.