Open AccessTLR4 upregulates CBS expression through NF-κB activation in a rat model of irritable bowel syndrome with chronic visceral hypersensitivity
Author(s) -
Bo Yuan,
Tang Wei-hong,
Lijuan Lu,
Yuan Zhou,
Hongyan Zhu,
Youlang Zhou,
Honghong Zhang,
Chuang-Ying Hu,
GuangYin Xu
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i28.8615
Subject(s) - pyrrolidine dithiocarbamate , downregulation and upregulation , tlr4 , irritable bowel syndrome , western blot , medicine , visceral pain , endocrinology , receptor , inflammation , pharmacology , chemistry , nf κb , nociception , biochemistry , gene
To investigate the roles of toll-like receptor 4 (TLR4) and nuclear factor (NF)-κB on cystathionine β synthetase (CBS) expression and visceral hypersensitivity in rats.