Open AccessTLR2andTLR4polymorphisms influence mRNA and protein expression in colorectal cancer
Author(s) -
Marcela Alcântara Proença,
Juliana Garcia de Oliveira,
Aline Cristina Targa Cadamuro,
Maysa Succi,
João Gomes Netinho,
Eny Maria Goloni-Bertolo,
Érika Cristina Pavarino,
Ana Elizabete Silva
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i25.7730
Subject(s) - microbiology and biotechnology , biology , taqman , colorectal cancer , immunohistochemistry , tlr2 , real time polymerase chain reaction , messenger rna , exon , tlr4 , receptor , gene , cancer , immunology , genetics
To evaluate the effect of promoter region polymorphisms of toll-like receptor (TLR)2-196 to -174del and TLR4-1607T/C (rs10759932) on mRNA and protein expression in tumor tissue and of TLR4+896A/G (rs4986790) on colorectal cancer (CRC) risk.