Open AccessLocally advanced undifferentiated carcinoma with osteoclast-like giant cells of the pancreas
Author(s) -
Hongqiao Gao,
Yinmo Yang,
Yan Zhuang,
Ping Liu
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i2.694
Subject(s) - giant cell , pancreas , medicine , splenectomy , histogenesis , gemcitabine , pathology , pancreatectomy , pancreaticoduodenectomy , osteoclast , carcinoma , chemotherapy , spleen , immunohistochemistry , receptor
Undifferentiated carcinoma with osteoclast-like giant cells of the pancreas (UCOGCP) is an unusual pancreatic neoplasm that represents < 1% of all pancreatic malignancies. Moreover, the giant cells of UCOGCP morphologically resemble the benign giant cells of bone tumors. Due to the rarity of this tumor type, the histogenesis and biologic behavior of UCOGCP remain controversial. Here, we report a case of UCOGCP that exhibited an invasive growth pattern involving infiltration of the adjacent bowel loop and portal vein, as well as superior mesenteric vein thrombosis. The patient underwent a distal pancreatectomy with splenectomy and partial colectomy, followed by four cycles of gemcitabine chemotherapy. No evidence of recurrence was detected after ten years. In addition to this case, clinical information on other UCOGCP cases reported in the English literature is summarized.