Open AccessAdvances in understanding and treating liver diseases during pregnancy: A review
Author(s) -
Kenya Kamimura,
Hiroyuki Abé,
Hirokazu Kawai,
Hiroteru Kamimura,
Yuji Kobayashi,
Minoru Nomoto,
Yoshinobu Aoyagi,
Shuji Terai
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i17.5183
Subject(s) - medicine , pregnancy , hyperemesis gravidarum , acute fatty liver of pregnancy , etiology , cholestasis of pregnancy , intensive care medicine , disease , liver disease , preeclampsia , fetus , eclampsia , obstetrics , bioinformatics , nausea , genetics , biology
Liver disease in pregnancy is rare but pregnancy-related liver diseases may cause threat to fetal and maternal survival. It includes pre-eclampsia; eclampsia; haemolysis, elevated liver enzymes, and low platelets syndrome; acute fatty liver of pregnancy; hyperemesis gravidarum; and intrahepatic cholestasis of pregnancy. Recent basic researches have shown the various etiologies involved in this disease entity. With these advances, rapid diagnosis is essential for severe cases since the decision of immediate delivery is important for maternal and fetal survival. The other therapeutic options have also been shown in recent reports based on the clinical trials and cooperation and information sharing between hepatologist and gynecologist is important for timely therapeutic intervention. Therefore, correct understandings of diseases and differential diagnosis from the pre-existing and co-incidental liver diseases during the pregnancy will help to achieve better prognosis. Therefore, here we review and summarized recent advances in understanding the etiologies, clinical courses and management of liver disease in pregnancy. This information will contribute to physicians for diagnosis of disease and optimum management of patients.