Open AccessReview on hepatic explant pathology of pediatric intestinal transplant recipients: Is it time for an oil change?
Author(s) -
Essam Imseis,
J. Marc Rhoads
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i17.5115
Subject(s) - medicine , cholestasis , fibrosis , parenteral nutrition , fish oil , hepatic fibrosis , gastroenterology , explant culture , fatty liver , pathology , fish <actinopterygii> , biology , biochemistry , in vitro , disease , fishery
A recent study attempts to add to the body of evidence that is emerging regarding the fish oil parenteral lipid product Omegaven™. The authors have shown from explant livers of children on chronic parenteral nutrition with Omegaven™ that biochemical improvement in cholestasis does not always reflect improvement in liver histology. These findings support 2 small case series that were previously published. Despite improvement and resolution of hyperbilirubinemia in all six infants, five of six infants had persistent or progressive hepatic fibrosis, while only one infant had regression of fibrosis. The study raises questions of whether there is a window of opportunity for efficacy of this preparation; also, an important question is if this omega-3 fatty acid-rich preparation is superior to newer "blended lipids" containing olive, coconut, soy, and fish oil.