Open AccessComplicated fecal microbiota transplantation in a tetraplegic patient with severeClostridium difficileinfection
Author(s) -
Thorsten Brechmann,
Justyna Swol,
Veronika Knop-Hammad,
Jörg Willert,
Mirko Aach,
Oliver Cruciger,
Wolff Schmiegel,
Thomas A. Schildhauer,
Uwe Hamsen
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i12.3736
Subject(s) - medicine , clostridium difficile , tigecycline , fidaxomicin , metronidazole , vancomycin , rifaximin , enterocolitis , tetraplegia , surgery , transplantation , antibiotics , pneumonia , anaerobic bacteria , spinal cord injury , microbiology and biotechnology , spinal cord , staphylococcus aureus , genetics , psychiatry , bacteria , biology
A 65-year-old male suffering from acute spinal cord injury leading to incomplete tetraplegia presented with severe recurrent Clostridium difficile (C. difficile) infection subsequent to antibiotic treatment for pneumonia. After a history of ineffective antimicrobial therapies, including metronidazole, vancomycin, fidaxomicin, rifaximin and tigecycline, leading to several relapses, the patient underwent colonoscopic fecal microbiota transplantation from his healthy son. Four days subsequent to the procedure, the patient showed a systemic inflammation response syndrome. Without detecting an infectious cause, the patient received antimicrobial treatment, including tigecycline, metronidazole, vancomycin via polyethylene glycol and an additional enema for a period of seven days, leading to a prompt recovery and no reported C. difficile infection relapse during a 12 wk follow up.