Open AccessNuclear factor kappa B role in inflammation associated gastrointestinal malignancies
Author(s) -
S Gambhir,
Dinesh Vyas,
Michael Hollis,
Apporva Aekka,
Arpita Vyas
Publication year - 2015
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v21.i11.3174
Subject(s) - inflammation , carcinogenesis , medicine , mediator , cancer , nfkb1 , immunology , cancer research , gastrointestinal cancer , colorectal cancer , biology , transcription factor , gene , genetics
Nuclear factor kappa B (NF-κB) has an established role in the regulation of innate immunity and inflammation. NF-κB is also involved in critical mechanisms connecting inflammation and cancer development. Recent investigations suggest that the NF-κB signaling cascade may be the central mediator of gastrointestinal malignancies including esophageal, gastric and colorectal cancers. This review will explore NF-κB's function in inflammation-associated gastrointestinal malignancies, highlighting its oncogenic contribution to each step of carcinogenesis. NF-κB's role in the inflammation-to-carcinoma sequence in gastrointestinal malignancies warrants stronger emphasis upon targeting this pathway in achieving greater therapeutic efficacy.