Open AccessTreatment of gastric cancer
Author(s) -
Michele Orditura,
Gennaro Galizia,
Vincenzo Sforza,
Valentina Gambardella,
Alessio Fabozzi,
Maria Maddalena Laterza,
Francesca Andreozzi,
Jole Ventriglia,
Beatrice Savastano,
Andrea Mabilia,
Eva Lieto,
Fortunato Ciardiello,
Ferdinando De Vita
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i7.1635
Subject(s) - medicine , cancer , chemotherapy , oncology , perioperative , cisplatin , lymph node , stage (stratigraphy) , trastuzumab , dissection (medical) , surgery , breast cancer , paleontology , biology
The authors focused on the current surgical treatment of resectable gastric cancer, and significance of peri- and post-operative chemo or chemoradiation. Gastric cancer is the 4(th) most commonly diagnosed cancer and the second leading cause of cancer death worldwide. Surgery remains the only curative therapy, while perioperative and adjuvant chemotherapy, as well as chemoradiation, can improve outcome of resectable gastric cancer with extended lymph node dissection. More than half of radically resected gastric cancer patients relapse locally or with distant metastases, or receive the diagnosis of gastric cancer when tumor is disseminated; therefore, median survival rarely exceeds 12 mo, and 5-years survival is less than 10%. Cisplatin and fluoropyrimidine-based chemotherapy, with addition of trastuzumab in human epidermal growth factor receptor 2 positive patients, is the widely used treatment in stage IV patients fit for chemotherapy. Recent evidence supports the use of second-line chemotherapy after progression in patients with good performance status.