Open AccessPrimary large cell neuroendocrine carcinoma in the common bile duct: First Asian case report
Author(s) -
Sung Bae Park,
Sun-Young Moon,
Young Joon Ryu,
Jeana Hong,
YangHee Kim,
Gi Bong Chae,
Seok Jin Hong
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i47.18048
Subject(s) - medicine , jaundice , common bile duct , lymph node , chemotherapy , bile duct , nausea , radiation therapy , bile duct cancer , neuroendocrine tumors , oncology , pathology , gastroenterology
Large cell neuroendocrine carcinoma (LCNEC) in the biliary system is a poorly differentiated, high-grade neuroendocrine tumor. These tumors exhibit aggressive behavior and an increased tendency for early nodal and distant metastases. Herein, we report an unusual case of a pure primary LCNEC of the common bile duct (CBD). A 75-year-old female presented with nausea and jaundice. The patient underwent a CBD excision with lymph node dissection. Upon histological and immunohistochemical examination, the tumor exhibited pure large cell-type neuroendocrine features. Metastases were noted in two of the eight lymph nodes. The patient was administered adjuvant chemotherapy. The patient's cancer recurred 7 mo after surgery, and the patient died from liver failure 5 mo after recurrence. The prognosis of LCNEC of CBD remains poor despite curative resection and adjuvant chemotherapy. The role of additional therapies, such as multimodal treatment including radiation therapy, must be further studied to improve the prognoses of patients.