Open AccessComputed tomography perfusion imaging as a potential imaging biomarker of colorectal cancer
Author(s) -
Koichi Hayano
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i46.17345
Subject(s) - colorectal cancer , medicine , imaging biomarker , angiogenesis , biomarker , neovascularization , perfusion , cancer , perfusion scanning , preclinical imaging , radiology , pathology , in vivo , magnetic resonance imaging , biology , biochemistry , microbiology and biotechnology
Neovascularization was reported to arise early in the adenoma-carcinoma sequence in colorectal cancer (CRC), and the importance of angiogenesis in cancer progression has been established. Computed tomography (CT) perfusion (CTP) based on high temporal resolution CT images enables evaluation of hemodynamics of tissue in vivo by modeling tracer kinetics. CTP has been reported to characterize tumor angiogenesis, and to be a sensitive marker for predicting recurrence or survival in CRC. In this review, we will discuss the biomarker value of CTP in the management of CRC patients.