Open AccessA huge adenosquamous carcinoma of the pancreas with sarcomatoid change: An unusual case report
Author(s) -
Binfeng Lu,
Chen Wang,
Jianzhong Yu,
Zhihong Shen,
Jianhui Yang
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i43.16381
Subject(s) - adenosquamous carcinoma , sarcomatoid carcinoma , pathology , pancreas , adenocarcinoma , immunohistochemistry , carcinoma , medicine , biology , cancer
Adenosquamous carcinoma rarely occurs in the pancreas, and is characterized by the presence of cellular components from both duct adenocarcinoma and squamous carcinoma. Here, we describe a rare case of pancreatic adenosquamous carcinoma with sarcomatous change. Immunohistochemistry showed that the sarcomatous lesion lost the epithelial marker and aberrantly expressed of acquired mesenchymal markers, which indicated that this special histological phenotype may be attributed to epithelial-mesenchymal transition. This case also indicated that a routine radical surgery without aggressive treatment strategies was still appropriate for adenosquamous carcinoma of the pancreas with sarcomatoid change.