Open AccessEffect of liver regeneration on malignant hepatic tumors
Author(s) -
Jihua Shi,
Pål–Dag Line
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i43.16167
Subject(s) - liver regeneration , regeneration (biology) , pathology , cancer research , progenitor cell , liver tumor , hepatectomy , biology , parenchyma , medicine , stem cell , microbiology and biotechnology , hepatocellular carcinoma , surgery , resection
Liver regeneration after major surgery may activate occult micrometastases and facilitate tumor growth, leading to liver tumor recurrence. Molecular changes during liver regeneration can provide a microenvironment that stimulates intrahepatic tumor propagation through alterations in cellular signaling pathways, where activation and proliferation of mature hepatocytes, hepatic progenitor cells, non-parenchymal liver cells might favor both liver regeneration and tumor growth. This review highlights recent advances of tumor growth and development in the regenerating liver, possible mechanisms and clinical implications.