Open AccessFXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation
Author(s) -
Jun Yao,
Chun-Suo Zhou,
Xiong Ma,
Bai-Qing Fu,
Li-Sheng Tao,
Chen Miao,
Yaping Xu
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i39.14430
Subject(s) - proinflammatory cytokine , farnesoid x receptor , medicine , endocrinology , inflammation , nonalcoholic fatty liver disease , fatty liver , biology , nuclear receptor , biochemistry , disease , transcription factor , gene
To examine the effect of farnesoid X receptor (FXR) activation by GW4064 on endotoxin-induced hepatic inflammation in nonalcoholic fatty liver disease (NAFLD) and the underlying mechanism.