Open AccessHelicobacter pyloriinfection, gastrin and cyclooxygenase-2 in gastric carcinogenesis
Author(s) -
Yun Shao,
Kai Sun,
Wei Xu,
Xiaolin Li,
Hong Shen,
Wei Sun
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i36.12860
Subject(s) - helicobacter pylori , gastrin , cancer , medicine , gastroenterology , carcinogenesis , epidemiology , helicobacter pylori infection , cyclooxygenase , gastritis , immunology , biology , enzyme , secretion , biochemistry
Gastric cancer is one of the most frequent neoplasms and a main cause of death worldwide, especially in China and Japan. Numerous epidemiological, animal and experimental studies support a positive association between chronic Helicobacter pylori (H. pylori) infection and the development of gastric cancer. However, the exact mechanism whereby H. pylori causes gastric carcinogenesis remains unclear. It has been demonstrated that expression of cyclooxygenase-2 (COX-2) is elevated in gastric carcinomas and in their precursor lesions. In this review, we present the latest clinical and experimental evidence showing the role of gastrin and COX-2 in H. pylori-infected patients and their possible association with gastric cancer risk.