Open AccessMicroRNA-31 expression in colorectal serrated pathway progression
Author(s) -
Hironori Aoki,
Katsuhiko Nosho,
Harukazu Igarashi,
Miki Ito,
Kei Mitsuhashi,
Takafumi Naito,
Eiko Yamamoto,
Tokuma Tanuma,
Masafumi Nomura,
Hiroyuki Maguchi,
Toshiya Shinohara,
Hiromu Suzuki,
Hiroyuki Yamamoto,
Yasuhisa Shinomura
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i34.12346
Subject(s) - hyperplastic polyp , microrna , colorectal cancer , lesion , pathology , cecum , colonoscopy , medicine , tumor progression , phenotype , cancer research , biology , cancer , gene , genetics
MicroRNAs have been increasingly recognized as useful biomarkers for colorectal cancers (CRC). We have recently observed that microRNA-31 (miR-31) expression is associated with BRAF mutation and prognosis in CRC. Moreover, high miR-31 expression is frequently detected in sessile serrated adenomas compared with hyperplastic polyps (HPs). These results suggest that miR-31 may contribute to the progression of serrated lesions. At a follow-up colonoscopy, we observed the case of a 75-year-old man with a 7-mm flat-elevated lesion in the cecum and diagnosed the lesion as an early invasive carcinoma with serrated features. Tissue specimens were obtained from the representative areas to compare the molecular alterations in the carcinoma component with those in the HP component. Higher miR-31 expression was observed in the carcinoma component (57-fold increase) and the HP component (8-fold increase) compared with the paired normal mucosa, suggesting that miR-31 may be one of the key molecules in serrated pathway progression.