Open AccessIntestinal obstruction caused by extramedullary hematopoiesis and ascites in primary myelofibrosis
Author(s) -
Xiuqing Wei,
Zongheng Zheng,
Y. Jin,
Tao Jin,
Kodjo-Kunale Abassa,
Zhiyuan Wen,
Chun-Kui Shao,
Wei H,
Bin Wu
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i33.11921
Subject(s) - extramedullary hematopoiesis , hepatosplenomegaly , myelofibrosis , medicine , ascites , differential diagnosis , anemia , haematopoiesis , bone marrow , pathology , gastroenterology , bowel obstruction , stem cell , surgery , biology , genetics , disease
Primary myelofibrosis (PMF) is a clonal hematopoietic stem cell disorder. It is characterized by bone marrow fibrosis, extramedullary hematopoiesis with hepatosplenomegaly and leukoerythroblastosis in the peripheral blood. The main clinical manifestations of PMF are anemia, bleeding, hepatosplenomegaly, fatigue, and fever. Here we report a rare case of PMF with anemia, small bowel obstruction and ascites due to extramedullary hematopoiesis and portal hypertension. The diagnosis was difficult to establish before surgery and the differential diagnosis is discussed.