Open AccessNatural history, treatment and prevention of hepatitis C recurrence after liver transplantation: Past, present and future
Author(s) -
Jérôme Dumortier,
Olivier Boillot,
Jean–Yves Scoazec
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i32.11069
Subject(s) - medicine , hepatocellular carcinoma , natural history , liver transplantation , cirrhosis , hepatitis c virus , hepatitis c , liver disease , gastroenterology , transplantation , immunology , virus
Hepatitis C virus (HCV)-related liver disease, including cirrhosis and hepatocellular carcinoma is the main indication for liver transplantation (LT) worldwide. Post-transplant HCV re-infection is almost universal and results in accelerated progression from acute hepatitis to chronic hepatitis, and liver cirrhosis. Comprehension and treatment of recurrent HCV infection after LT have been major issues for all transplant hepatologists and transplant surgeons for the last decades. The aim of this paper is to review the evolution of our knowledge on the natural history of HCV recurrence after LT, including risk factors for disease progression, and antiviral therapy. We will focus our attention on possible ways (present and future) to improve the final long-term results of LT for HCV-related liver disease.