Open AccessCytoprotective effects of amifostine, ascorbic acid and N-acetylcysteine against methotrexate-induced hepatotoxicity in rats
Author(s) -
Sami Akbulut,
Hülya Elbe,
Cengiz Eriş,
Zümrüt Doğan,
Gülten Toprak,
Emrah Otan,
Erman Erdemli,
Yusuf Türköz
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i29.10158
Subject(s) - malondialdehyde , ascorbic acid , alkaline phosphatase , glutathione , pharmacology , chemistry , superoxide dismutase , oxidative stress , amifostine , xanthine oxidase , methotrexate , acetylcysteine , bilirubin , catalase , medicine , toxicity , antioxidant , biochemistry , enzyme , food science
To investigate the potential role of oxidative stress and the possible therapeutic effects of N-acetyl cysteine (NAC), amifostine (AMF) and ascorbic acid (ASC) in methotrexate (MTX)-induced hepatotoxicity.