Open AccessPeroxisome proliferator-activated receptor α, a potential therapeutic target for alcoholic liver disease
Author(s) -
Yuemin Nan,
Rongqi Wang,
Na Fu
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i25.8055
Subject(s) - steatohepatitis , alcoholic liver disease , steatosis , fatty liver , cirrhosis , liver injury , peroxisome proliferator activated receptor , alcoholic fatty liver , medicine , hepatocellular carcinoma , peroxisome proliferator activated receptor alpha , oxidative stress , fibrosis , chronic liver disease , lipid metabolism , liver disease , cancer research , receptor , biology , disease , nuclear receptor , biochemistry , transcription factor , gene
Alcoholic liver injury represents a progressive process with a range of consequences including hepatic steatosis, steatohepatitis, liver fibrosis, cirrhosis, and hepatocellular carcinoma. Targeting key molecular regulators involved in the development of alcoholic liver injury may be of great value in the prevention of liver injury. Peroxisome proliferator-activated receptor α (PPARα) plays a pivotal role in modulation of hepatic lipid metabolism, oxidative stress, inflammatory response and fibrogenesis. As such, PPARα may be a potential therapeutic target for the treatment of alcoholic liver disease.