Open AccessDetection of promoter hypermethylation of Wnt antagonist genes in fecal samples for diagnosis of early colorectal cancer
Author(s) -
Hu Zhang,
Yufan Zhu,
Yaqiong Wu,
Ping Zhang,
Jian Qi
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i20.6329
Subject(s) - dna methylation , colorectal cancer , fecal occult blood , methylation , adenoma , medicine , gastroenterology , hyperplastic polyp , cancer , cancer research , biology , gene , colonoscopy , gene expression , genetics
To investigate the feasibility of detecting aberrantly hypermethylated Wnt-antagonist gene promoters (SFRP2 and WIF-1) in fecal DNA as non-invasive biomarkers for early colorectal cancer (CRC).