Open AccessParticipation of microbiota in the development of gastric cancer
Author(s) -
Lili Wang,
Xinjuan Yu,
Shuai Zhan,
Sheng-Jiao Jia,
Zibin Tian,
Qi Dong
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i17.4948
Subject(s) - fusobacteria , helicobacter pylori , firmicutes , cancer , actinobacteria , proteobacteria , biology , bacteroidetes , stomach , helicobacter , capnocytophaga , fusobacterium , microbiology and biotechnology , bacteria , bacteroides , genetics , biochemistry , 16s ribosomal rna
There are a large number of bacteria inhabiting the human body, which provide benefits for the health. Alterations of microbiota participate in the pathogenesis of diseases. The gastric microbiota consists of bacteria from seven to eleven phyla, predominantly Proteobacteria, Firmicutes, Bacteroidetes, Actinobacteria and Fusobacteria. Intrusion by Helicobacter pylori (H. pylori) does not remarkably interrupt the composition and structure of the gastric microbiota. Absence of bacterial commensal from the stomach delays the onset of H. pylori-induced gastric cancer, while presence of artificial microbiota accelerates the carcinogenesis. Altered gastric microbiota may increase the production of N-nitroso compounds, promoting the development of gastric cancer. Further investigation of the carcinogenic mechanisms of microbiota would benefit for the prevention and management of gastric cancer.