Open AccessResveratrol inhibits collagen I synthesis by suppressing IGF-1R activation in intestinal fibroblasts
Author(s) -
Ping Li,
Meilan Liang,
Ying Zhu,
Yuhan Gong,
Yun Wang,
Ding Heng,
Lin Lin
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i16.4648
Subject(s) - resveratrol , chemistry , blot , fibrosis , type i collagen , kinase , microbiology and biotechnology , signal transduction , insulin like growth factor , mapk/erk pathway , growth factor , endocrinology , medicine , biology , biochemistry , receptor , gene
To investigate whether resveratrol (3,4,5-trihydroxy-trans-stilbene) inhibits collagen I synthesis induced by insulin growth factor-1 (IGF-1) in intestinal fibroblasts, and to explore the possible molecular mechanisms.