Open AccessHyperoxia accelerates progression of hepatic fibrosis by up-regulation of transforming growth factor-β expression
Author(s) -
Sang Hwa Lee,
Sung Il Im,
Hyun Soo Kim
Publication year - 2014
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v20.i11.3011
Subject(s) - hyperoxia , cirrhosis , hepatic fibrosis , thioacetamide , endocrinology , medicine , fibrosis , hypoxia (environmental) , transforming growth factor , biology , hepatic stellate cell , pathology , chemistry , lung , oxygen , organic chemistry
To investigate the effect of hypoxia or hyperoxia on the progression of hepatic fibrosis and to examine the role of transforming growth factor-β (TGF-β) in the livers of rats exposed to hypoxic or hyperoxic conditions.