Open AccessSevere gastrointestinal mucositis following high dose melphalan therapy for multiple myeloma
Author(s) -
Sanjeev Sharma,
Anil Handoo,
Deepak Choudhary,
Gaurav Dhamija,
Nitin Gupta
Publication year - 2013
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v19.i5.784
Subject(s) - mucositis , medicine , multiple myeloma , melphalan , gastrointestinal tract , ileus , complication , perforation , chemotherapy , gastroenterology , surgery , materials science , punching , metallurgy
Mucositis is a known complication following use of chemotherapy, but fatal mucositis is unusual and management of such cases may be challenging. Pathologically there is denudation of mucosa of gastrointestinal tract. Severe cases can develop ileus and even perforation of bowel wall. We report here a case of multiple myeloma who developed World Health Organization grade 4 gut mucositis following the use of high dose melphalan with the expulsion of "intestine-like" material.