Open AccessBeyond white light endoscopy: The role of optical biopsy in inflammatory bowel disease
Author(s) -
Julia Liu,
Aldona Dlugosz,
Helmut Neumann
Publication year - 2013
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v19.i43.7544
Subject(s) - inflammatory bowel disease , dysplasia , medicine , biopsy , ulcerative colitis , endomicroscopy , endoscopy , disease , pathology , gastroenterology , confocal , geometry , mathematics
In this review, we will discuss the use of two optical biopsy modalities in inflammatory bowel disease (IBD). The two techniques reviewed here are confocal laser endomicroscopy and endocytoscopy. We will describe the technical performance of the procedure, discuss the clinical indications for optical biopsy in IBD, and highlight active research areas with respect to the pathogenesis of IBD. Clinical indications for optical biopsies in IBD include assessment of mucosal inflammation, dysplasia detection and evaluation of cell shedding for disease relapse. Research application in the area of barrier dysfunction will also be discussed.