Open AccessPhysiological and molecular biochemical mechanisms of bile formation
Author(s) -
Vasiliy Ivanovich Reshetnyak
Publication year - 2013
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v19.i42.7341
Subject(s) - enterohepatic circulation , hepatocyte , biliary tract , bile pigments , biochemistry , bile acid , bone canaliculus , cholestasis , chemistry , biology , medicine , endocrinology , bilirubin , anatomy , in vitro
This review considers the physiological and molecular biochemical mechanisms of bile formation. The composition of bile and structure of a bile canaliculus, biosynthesis and conjugation of bile acids, bile phospholipids, formation of bile micellar structures, and enterohepatic circulation of bile acids are described. In general, the review focuses on the molecular physiology of the transporting systems of the hepatocyte sinusoidal and apical membranes. Knowledge of physiological and biochemical basis of bile formation has implications for understanding the mechanisms of development of pathological processes, associated with diseases of the liver and biliary tract.