Open AccessAlpha-fetoprotein: A controversial prognostic biomarker for small hepatocellular carcinoma
Author(s) -
Mohamed Asrih,
Sébastien Lenglet,
François Mach,
Fabrizio Montecucco
Publication year - 2013
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v19.i3.328
Subject(s) - hepatocellular carcinoma , medicine , biomarker , cirrhosis , histopathology , oncology , alpha fetoprotein , carcinoma , gastroenterology , pathology , biology , biochemistry
The assessment of the prognosis in patients with early hepatocellular carcinoma represents a hot-topic issue that requires further improvements and clarifications. The life expectancy of the patients has been shown to depend on several clinical and histological parameters (such as patient's general conditions, macroscopic tumor morphology and histopathology). Recently, the prognostic role of some biomarkers [i.e., alpha-fetoprotein (AFP)] has been also investigated with controversial findings mainly on the assessment of patient survival. The study by Giannini et al failed to show a prognostic value of AFP on survival of patients with well-compensated cirrhosis and small hepatocellular carcinoma. Since the study presents some limitations, a larger clinical trial is needed to clarify the potential prognostic role of serum AFP levels in these patients.