Tumor-infiltrating B cells come into vogue | Zendy

Michael Linnebacher | Zendy

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Tumor-infiltrating B cells come into vogue

Author(s) -

Michael Linnebacher

Publication year - 2013

Publication title -

world journal of gastroenterology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.427

H-Index - 155

eISSN - 2219-2840

pISSN - 1007-9327

DOI - 10.3748/wjg.v19.i1.8

Subject(s) - cytotoxic t cell , tumor infiltrating lymphocytes , infiltration (hvac) , immune system , cancer research , lymphocyte , immunology , medicine , biology , immunotherapy , genetics , physics , in vitro , thermodynamics

Lymphocyte infiltration into solid tumors has been recognized as a main determinator of positive prognosis. For the most part this is attributed to cytotoxic T cells capable of directly destroying malignant cells. However, when considering the complex composition of the human immune system, recent findings of Nielsen et al on a potentially central role of tumor-infiltrating B cells is not really surprising. In this commentary article, I want to highlight the enormous potential impact of this observation for basic and translational research, prognostic procedures and ultimately for the development of future therapeutic concepts.

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