Open AccessGermline mutation analysis ofMLH1andMSH2in Malaysian Lynch syndrome patients
Author(s) -
Mohd Nizam Zahary,
Gurjeet Kaur,
Muhammad Radzi Abu Hassan,
Harjinder Singh,
Venkatesh R Naik,
Ravindran Ankathil
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i8.814
Subject(s) - msh2 , germline mutation , biology , microbiology and biotechnology , missense mutation , mlh1 , exon , lynch syndrome , nonsense mutation , mutation , transversion , genetics , gene mutation , germline , cancer research , dna mismatch repair , gene , dna repair
To investigate the protein expression profile of mismatch repair (MMR) genes in suspected cases of Lynch syndrome and to characterize the associated germline mutations.