Open Access(Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione protects rats from carbon tetrachloride-induced liver injury and fibrogenesis
Author(s) -
Zhi-Zhi Chen,
Zhenglin Wang,
Cheng Deng,
Hao Zheng,
Linyu Li,
Liang Ma,
Ye Xia,
Yanlin Ma,
Caifeng Xie,
Lijuan Chen,
Yuquan Wei
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i7.654
Subject(s) - carbon tetrachloride , liver injury , intraperitoneal injection , nitric oxide synthase , h&e stain , chemistry , pharmacology , medicine , ccl4 , nitric oxide , endocrinology , immunohistochemistry , organic chemistry
To evaluate the hepatoprotective roles of (Z)-5-(4-methoxybenzylidene)thiazolidine-2,4-dione (SKLB010) against carbon tetrachloride (CCl₄)-induced acute and chronic liver injury and its underlying mechanisms of action.