Open AccessUGT1A1predicts outcome in colorectal cancer treated with irinotecan and fluorouracil
Author(s) -
Yan Wang,
Lin Shen,
g Xu,
Jinwan Wang,
Shunchang Jiao,
Zeyuan Liu,
Jianming Xu
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i45.6635
Subject(s) - irinotecan , regimen , colorectal cancer , fluorouracil , folfiri , medicine , genotype , sn 38 , gastroenterology , pharmacology , biology , oncology , chemotherapy , cancer , gene , genetics
To evaluate effects of UDP-glucuronosyltransferase1A1 (UGT1A1) and thymidylate synthetase (TS) gene polymorphisms on irinotecan in metastatic colorectal cancer (mCRC).