Open AccessLentiviral vector-mediated down-regulation of IL-17A receptor in hepatic stellate cells results in decreased secretion of IL-6
Author(s) -
Sheng-Chu Zhang,
Yijing Zheng,
Panpan Yu,
Tan Hooi Min,
Fuxiang Yu,
Chao Ye,
Yuan-kang Xie,
Qiyu Zhang
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i28.3696
Subject(s) - small hairpin rna , mapk/erk pathway , hepatic stellate cell , p38 mitogen activated protein kinases , kinase , phosphorylation , microbiology and biotechnology , receptor , blot , extracellular , biology , interleukin 17 , chemistry , medicine , endocrinology , cell culture , cytokine , biochemistry , immunology , gene knockdown , genetics , gene
To investigate the mechanism of interleukin (IL)-6 secretion through blocking the IL-17A/IL-17A receptor (IL-17RA) signaling pathway with a short hairpin RNA (shRNA) in hepatic stellate cells (HSCs) in vitro.