Open AccessA pediatric non-protein losing Menetrier's disease successfully treated with octreotide long acting release
Author(s) -
Giovanni Di Nardo,
Salvatore Oliva,
Marina Aloi,
Federica Ferrari,
Simone Frediani,
Adriana Marcheggiano,
Salvatore Cucchiara
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i21.2727
Subject(s) - octreotide , medicine , biopsy , gastroenterology , endoscopic mucosal resection , gastrectomy , refractory (planetary science) , surgery , endoscopy , somatostatin , cancer , physics , astrobiology
Pediatric Menetrier's disease (MD) is an uncommon, acute, self-limited hypertrophic gastropathy characterized by enlarged gastric folds associated with epithelial hyperplasia and usually accompanied by protein losing gastropathy. Gastric cytomegalovirus infection is found in one third of MD children and its treatment is often associated with remission. Diagnosis often requires full-thickness biopsy due to inability to detect typical histological findings with conventional endoscopic biopsy. We report an uncommon case of non self-limited pediatric MD needing endoscopic mucosal resection for diagnosis which was then successfully treated with octreotide long-acting release (LAR). To the best of our knowledge, this is the first pediatric MD case successfully treated with octreotide LAR. Our experience suggests octreotide LAR as treatment for refractory MD before gastrectomy.