Open AccessAnti-tumor effect of 5-aza-2'-deoxycytidine by inhibiting telomerase activity in hepatocellular carcinoma cells
Author(s) -
Shuang-fen Tao,
Changsong Zhang,
Xianling Guo,
Ye Xu,
Shanshan Zhang,
Jianrui Song,
Rong Li,
Mengchao Wu,
Lixin Wei
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i19.2334
Subject(s) - telomerase , telomerase reverse transcriptase , demethylating agent , microbiology and biotechnology , methylation , cancer research , dna methylation , cell culture , chemistry , biology , gene expression , gene , biochemistry , genetics
To investigate the effect of the demethylating reagent 5-aza-2'-deoxycitidine (DAC) on telomerase activity in hepatocellular carcinoma (HCC) cell lines, SMMC-7721 and HepG2.