Open AccessGastrointestinal and hepatic complications of hematopoietic stem cell transplantation
Author(s) -
Hande H. Tuncer,
Naveed Rana,
Can Milani,
Angela Darko,
Samer Al-Homsi
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i16.1851
Subject(s) - medicine , hematopoietic stem cell transplantation , transplantation , stem cell , incidence (geometry) , graft versus host disease , disease , intensive care medicine , pathogenesis , complication , haematopoiesis , immunology , surgery , biology , optics , genetics , physics
Recognition and management of gastrointestinal and hepatic complications of hematopoietic stem cell transplantation has gained increasing importance as indications and techniques of transplantation have expanded in the last few years. The transplant recipient is at risk for several complications including conditioning chemotherapy related toxicities, infections, bleeding, sinusoidal obstruction syndrome, acute and chronic graft-versus-host disease (GVHD) as well as other long-term problems. The severity and the incidence of many complications have improved in the past several years as the intensity of conditioning regimens has diminished and better supportive care and GVHD prevention strategies have been implemented. Transplant clinicians, however, continue to be challenged with problems arising from human leukocyte antigen-mismatched and unrelated donor transplants, expanding transplant indications and age-limit. This review describes the most commonly seen transplant related complications, focusing on their pathogenesis, differential diagnosis and management.