Open AccessPolymorphisms of theTLR2andTLR4genes are associated with risk of gastric cancer in a Brazilian population
Author(s) -
Juliana Garcia de Oliveira,
Ana Elizabete Silva
Publication year - 2012
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v18.i11.1235
Subject(s) - genotype , odds ratio , tlr2 , gastroenterology , helicobacter pylori , chronic gastritis , medicine , gastritis , single nucleotide polymorphism , cancer , population , allele , biology , haplotype , immunology , tlr4 , gene , genetics , receptor , environmental health
To investigate toll-like receptor 2 (TLR2) -196 to -174 del, and TLR4 (+896A/G rs4986790 and +1196C/T rs4986791) polymorphisms at risk of chronic gastritis and gastric cancer in a Brazilian population and association of gastric lesions with risk factors such as smoking, alcohol intake and Helicobacter pylori infection.