Open AccessHaemostatic system in inflammatory bowel diseases: New players in gut inflammation
Author(s) -
Franco Scaldaferri,
Stefano Lancellotti,
Marco Pizzoferrato,
Raimondo De Cristofaro
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - Uncategorized
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i5.594
Subject(s) - medicine , inflammatory bowel disease , inflammation , ulcerative colitis , pathogenesis , coagulation , immunology , sepsis , disease , crohn's disease , inflammatory bowel diseases , colitis , pathology
Inflammation and coagulation constantly influence each other and are constantly in balance. Emerging evidence supports this statement in acute inflammatory diseases, such as sepsis, but it also seems to be very important in chronic inflammatory settings, such as inflammatory bowel disease (IBD). Patients with Crohn's disease and ulcerative colitis have an increased risk of thromboembolic events, and several abnormalities concerning coagulation components occur in the endothelial cells of intestinal vessels, where most severe inflammatory abnormalities occur. The aims of this review are to update and classify the type of coagulation system abnormalities in IBD, and analyze the strict and delicate balance between coagulation and inflammation at the mucosal level. Recent studies on possible therapeutic applications arising from investigations on coagulation abnormalities associated with IBD pathogenesis will also be briefly presented and critically reviewed.