Open AccessAG490: An inhibitor of hepcidin expressionin vivo
Author(s) -
Shuping Zhang,
Zhe Wang,
Lixin Wang,
Sijin Liu
Publication year - 2011
Publication title -
world journal of gastroenterology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.427
H-Index - 155
eISSN - 2219-2840
pISSN - 1007-9327
DOI - 10.3748/wjg.v17.i45.5032
Subject(s) - hepcidin , inflammation , anemia , in vivo , iron homeostasis , medicine , endocrinology , hormone , immunology , metabolism , biology , microbiology and biotechnology
A liver-produced hormone, hepcidin, appears to be the key player in iron metabolism. The overexpression of hepcidin is the underlying cause of anemia of inflammation. The identification of compounds inhibiting hepcidin expression could ameliorate anemia associated with inflammation. In the current study, we have demonstrated for the first time that AG490 significantly abolishes hepcidin expression in mice. Our work represents a novel approach to suppress hepcidin expression for treatment of anemia of inflammation and anemias occurring under other conditions.